dc.contributor.advisor | Tiirats, Toomas | |
dc.contributor.author | Raux, Louise Anastasie Sylvie | |
dc.date.accessioned | 2022-05-17T07:12:34Z | |
dc.date.available | 2022-05-17T07:12:34Z | |
dc.date.issued | 2022 | |
dc.identifier.uri | http://hdl.handle.net/10492/7374 | |
dc.description | Final Thesis
Curriculum in Veterinary Medicine | eng |
dc.description.abstract | Canine endocrinopathies are frequently encountered in general practice. The prevalence and
the signalment of the disease differ depending on the affected hormone. Moreover, some
endocrine disorders (e.g., hypoadrenocorticism) are notorious for their non-specific signs,
making them challenging to diagnose. Knowledge of the clinical presentation of
endocrinopathies is imperative for their recognition and treatment. This study aims to assess
the signalment and hallmarks associated with common canine endocrinopathies
(hypothyroidism, hypoadrenocorticism, hyperadrenocorticism, and diabetes mellitus) by
analyzing clinical endocrine cases obtained in selected clinics in France and Estonia. In
addition, current diagnostic methods and treatment options of chronic hypoadrenocorticism
are discussed to provide a better understanding of this pathology.
Endocrine cases were obtained through the clinics’ management software. The following
variables were collected: breed, sex, age, age at time of diagnosis, concurrent disease,
weight, neutered status, clinical signs, laboratory tests used, diagnosis, and treatment. Some
results obtained from the analysis did not match the data found in scientific literature. In
this paper, hypothyroidism affected females more frequently than males (41.2% vs. 58.8%,
respectively). Sterilized females (70.0%) were more often affected than intact females
(30.0%) whereas sterilized males developed hypothyroidism more commonly than intact
males (71.4% vs. 28.6%, respectively). Hyperadrenocorticism was equally represented in
females and males. Regarding diabetes mellitus, non-sterilized females were at higher odds
than sterilized females (57.1% vs. 42.8%, respectively). Finally, hypoadrenocorticism was
overrepresented in Yorkshires (33.3%). The treatment of chronic hypoadrenocorticism
differed between countries: desoxycorticosterone pivalate and prednisone were used in
France, while fludrocortisone acetate and prednisone in Estonia.
Innovations in terms of diagnosis and treatment of hypoadrenocorticism have recently been
offered. Based on studies, low-dose adrenocorticotropic hormone stimulation test is as
efficient as a standard dose for screening dogs suspected of hypoadrenocorticism, and a
decreased dose of desoxycorticosterone pivalate could be employed to stabilize electrolytes.
I suggest that more attention should be paid to these interesting findings, since they
potentially could modify the current approach to managing chronic hypoadrenocorticism. | eng |
dc.description.abstract | Koerte endokrinopaatiat kohtab veterinaarpraktikas sageli. Olenevalt hormonaalsest häirest on
haiguse levimus ja kliiniline pilt erinev. Lisaks on endokrinoloogilised probleemid (nt
hüpoadrenokortitsism) tuntud oma mittespetsiifiliste nähtude poolest, mistõttu on nende
diagnoosimine keeruline. Teadmised endokrinopaatiatest kliinilises võtmes on hädavajalikud
selle avastamiseks ja raviks. Käesoleva uuringu eesmärk on hinnata koerte endokrinopaatiate
(hüpotüreoidism, hüpoadrenokortitsism, hüperadrenokortitsism ja suhkurtõbi) signaale ja
tunnuseid. Analüüsiti Prantsusmaa ja Eesti kliinikutest kogutud andmeid. Lisaks käsitletakse
põhjalikumalt tänapäeval kasutatavaid kroonilise hüpokortitsismi diagnoosimisvõtteid ja
ravivõimalusi.
Endokriinsed haigusjuhtumid koguti kliinikutes kasutatava haldustarkvara kaudu ja koostati
andmebaas järgmistest muutujatest: tõug, sugu, vanus, vanus diagnoosimise hetkel, kaasnevad
haigused, kaal, kastreeritud/steriliseeritud, kliinilised tunnused, kasutatud laboratoorsed testid,
täpne diagnoos ja ravi. Teostatud analüüsi tulemused
ei ühtinud alati teaduskirjandusest leitud andmetega. Hüpotüreoidismi haigestusid sagedamini
emaseid (58.8%) kui isaseid (41.2%) koerad. Seejuures oli haigestunute seas rohkem
steriliseeritud (70.0%) kui steriliseerimata emaseid (30.0%), samas kui kastreeritud isastel
tekkis kilpnäärme alatalitlus sagedamini kui kastreerimat isastel (vastavalt 71.4% vs. 28.6%).
Hüperadrenokortitsismi esines võrdselt nii emastel kui ka isastel koertel. Diabeet esines
sagedamini steriliseerimata emastel kui steriliseeritud emastel (vastavalt 57.1% vs 42.8%).
Tõugude kokkuvõttes oli hüpoadrenokortitsismi võrreldes teistega rohkem Yorkshire terjeritel
(33.3%). Kroonilise hüpoadrenokortitsismi ravi oli riigiti erinev. Prantsusmaal kasutati
valdavalt desoksükortikosteroonpivalaati ja prednisooni ning Eestis fludrokortisoonatsetaati ja
prednisooni.
Hüpoadrenokortisismi diagnoosimise jaravi vallas on toimunud viimasel aja arengud.Uuringu
te põhjal onmadala doosiga adrenokortikotroopse hormooni stimulatsiooni testsama tõhus hüp
oadrenokortikismi kahtluse kiinnitamiseks koertele kui standardannus ning elektrolüütide stab
iliseerimiseks võib kasutada desoksükortikosteroonpivalaadi madalamad annust.Soovitan pöö
rata rohkem tähelepanu nendele leidudele, kuna needvõivad potentsiaalselt muuta praegust lä
henemisviisi kroonilise hüpoadrenokortisismi ravimisele ning diagnoosimisele. | est |
dc.publisher | Eesti Maaülikool | |
dc.subject | magistritööd | est |
dc.subject | master thesis | eng |
dc.subject | endocrinology | eng |
dc.subject | hypoadrenocorticism | eng |
dc.subject | desoxycortisterone pivalate | eng |
dc.subject | fludrocortisone acetate | eng |
dc.title | Retrospective analysis of clinical endocrine cases in dogs in selected veterinary clinics of France and Estonia | eng |
dc.title.alternative | Koerte endokrinoloogiliste haigusjuhtumite retrospektiivne analüüs erinevates kliinikutes Prantsusmaal ja Eestis | est |
dc.type | Master Thesis | eng |
dc.date.defensed | 2022-06-09 | |
rioxxterms.freetoread.startdate | 09.09.2022 | |