Tartaric acid synthetic derivatives effect on phytopathogenic bacteria
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Kuupäev
2022
Kättesaadav alates
Ajakirja pealkiri
Ajakirja ISSN
Köite pealkiri
Kirjastaja
Estonian University of Life Sciences
Abstrakt
The scientific goals of current research were devoted to targeted derivatization of
natural tartaric acid (TA) for the enhancement of antimicrobial properties of it such as like the
effects of them on multi-drug resistant phytopathogenic bacteria, depends to their structure
features and the genetic parameters of studied microorganisms. The main utilitarian goal is to
develop new class of antimicrobial biodegradable compounds with possible prospective
application as moresafe alternative to traditional antibiotics applicable for: agriculture,
horticulture, food industry as well as in medicine. These compounds were developed in basic
research laboratory: ‘Agrarian Pesticide Creation and The Quality Control’ at National
Polytechnic University of Armenia (NPUA). TA and tartrates are safe antimicrobial food
additives. According to the results of in vitro studies, the synthesized cyclohexyl-, benzyl- and
phenyl- derivatives of it in the form of amine complex salts (correspondently CAS, BAS and
PhAS) and cyclic imides (correspondently CI, BI and PhI) are effective against the model multidrug resistant strains of Gram-negative microorganisms. Bactericidal effects of TA derivatives
were demonstrated on 19 model native soil strains of phytopathogenic Xanthomonas beticola
(6 strains), X. vesicatoria and Pseudomonas syringae (13 strains) representatives, which are
differing in antibiotic resistance. Regarding the transformation results, the absence of transfer of
resistance to TA imides and amine complex salts by plasmids, makes them promising objects for
further research. Primary studies have not shown any antibacterial effect on various nonpathogenic soil bacteria (Pseudomonas chlororaphis, P. taetrolens, etc.). The described
compounds are recommended for further more detailed toxicological studies.
Kirjeldus
Received: February 19th, 2022 ; Accepted: May 25th, 2022 ; Published: June 27th, 2022 ; Correspondence: arevshadvartanyan@mail.ru
Märksõnad
antimicrobial agents, complex salts of tartaric acid, imides of tartaric acid, multidrug resistance, phytopathogen, Pseudomonas, Xanthomonas, articles