Sources of Human Campylobacteriosis Cases in Estonia and the Genomic Associations with Broiler Chicken Meat Isolates
Laen...
Kuupäev
2026
Kättesaadavus
Ajakirja pealkiri
Ajakirja ISSN
Köite pealkiri
Kirjastaja
MDPI
Abstrakt
This study used three complementary datasets to investigate the relationship between
human Campylobacter infections in Estonia and potential sources. A targeted dataset of 15 C.
jejuni genomes with overlapping sequence types from human cases and broiler chicken meat
was analysed using genotyping and in silico antimicrobial resistance profiling, alongside
20 human isolates for source attribution. Additionally, 12,111 isolates were analysed to
provide population-level context. The core genome multilocus sequence typing showed a
high similarity (less than three allelic differences) between the human and broiler isolates of
ST122, ST464, and ST7355, indicating poultry as a likely source, whereas ST9882 was more
divergent (13–18 allelic differences). The resistance profiles were consistent within ST122,
ST464, and ST7355, and all were resistant to ciprofloxacin, nalidixic acid, ampicillin, and
tetracycline, while ST9882 additionally exhibited aminoglycoside (streptomycin) resistance.
The source attribution linked 77.8% of the human cases to chicken and 22.2% to cattle. A
novel genotype, ST11001, was identified in humans and attributed to cattle source, while C.
coli isolates were linked to birds and sheep. Poultry dominated the larger dataset (87.3%).
Gastroenteritis was the predominant clinical presentation (98.5%), whereas ST22 and ST122
were associated with Guillain–Barré syndrome. These findings support poultry as a major
reservoir of human Campylobacter infections and highlight the need for coordinated crossborder
surveillance.
Kirjeldus
Märksõnad
C. jejuni, C. coli, cgMLST, AMR, source attribution, articles
Viide
Ivanov, I., Takkinen, H. K., Takkinen, J., Roasto, M., & Mäesaar, M. (2026). Sources of Human Campylobacteriosis Cases in Estonia and the Genomic Associations with Broiler Chicken Meat Isolates. Pathogens, 15(5), 539. https://doi.org/10.3390/pathogens15050539