Effect of long detomidine constant rate infusion with and without vatinoxan on gastrointestinal motility in healthy horses
| dc.contributor.advisor | Raekallio, Marja (advisor) | |
| dc.contributor.advisor | Semjonov, Aleksandr (advisor) | |
| dc.contributor.author | Rivera Pöyhönen, Rebecca | |
| dc.date.accessioned | 2024-06-11T11:30:36Z | |
| dc.date.available | 2024-06-11T11:30:36Z | |
| dc.date.defensed | 2024-06-13 | |
| dc.date.issued | 2024 | |
| dc.description | Final Thesis Curriculum in Veterinary Medicine | eng |
| dc.description.abstract | Detomidine is an alpha-2-agonist commonly used in horse sedation. It has negative side effects on gastrointestinal motility that can increase the risk of colic. This experimental crossover study evaluated the effects of a peripherally acting alpha-2-antagonist (vatinoxan) on gastrointestinal motility in healthy horses sedated with detomidine. Eight horses received two four-hour infusions of either detomidine hydrochloride (0.01 mg/kg + 0.015 mg/kg/h IV) alone or combined with vatinoxan hydrochloride (0.15 mg/kg + 0.05 mg/kg/h IV). Small plastic spheres were administered with a nasogastric tube before the start of infusion. Borborygmi scores were monitored. The time for the first defecation was marked down. The excretion of the spheres, faecal output, and frequency of defecation were monitored repeatedly after the end of the infusion. Reduction in borborygmi scores was less with the combination of detomidine and vatinoxan than with detomidine (p<0.05). With vatinoxan, the mean cumulative weight of faeces and the cumulative number of faecal piles were higher during the first 8 hours after the end of infusion than with detomidine alone (p<0.05), and the horses defecated sooner (p=0.01). The plastic spheres were excreted faster with detomidine than with the combination (p<0.05). In conclusion, combining vatinoxan with detomidine improved the borborygmi score, and horses passed faeces sooner, more frequently, and in higher quantities. Therefore, vatinoxan may aid gastrointestinal motility in horses treated with detomidine, although this conclusion is not supported by the slower excretion of spheres in the presence of vatinoxan. Thus, further studies are required to resolve these conflicting results. | eng |
| dc.description.abstract | Detomidiin on alfa-2-agonist, mida kasutatakse sageli hobuste rahustamiseks. Sellel on negatiivsed kõrvalmõjud seedetrakti liikuvusele, mis võib suurendada koolikute riski. See eksperimentaalne ristuuring hindas perifeerselt toimiva alfa-2-antagonisti (vatinoksaani) mõju solemotoorikale tervetel detomidiiniga rahustatud hobustel. Kaheksa hobust said kas ainult detomidiinvesinikkloriidi (0,01 mg/kg + 0,015 mg/kg/h IV) või kombinatsioonis vatinoksaani vesinikkloriidiga (0,15 mg/kg + 0,05 mg/kg/h IV) kaks neljatunnist infusiooni. Enne infusiooni algust manustati väikesed värvilised plastikkerakesed nasogastraalsondiga. Borborygmi skoori jälgiti. Esimese roojamise aeg fikseeriti. Kerakeste eritumist, väljaheite kogust ja roojamise sagedust jälgiti korduvalt pärast infusiooni lõppu. Borborygmi hinde vähenemine oli detomidiini ja vatinoksaani kombinatsiooniga väiksem kui ainult detomidiiniga (p<0,05). Vatinoksaaniga oli keskmine väljaheite kogukaal ja väljaheitekoguste koguarv esimese 8 tunni jooksul pärast infusiooni lõppu suurem kui ainult detomidiiniga (p<0,05) ja hobused roojasid varem (p=0,01). Plastikkerakesed eritusid detomidiiniga kiiremini kui kombinatsiooniga (p<0,05). Kokkuvõttes parandas vatinoksaani kombineerimine detomidiiniga Borborygmi skoori ning hobused eritasid väljaheiteid kiiremini, sagedamini ja suuremates kogustes. Seega võib vatinoksaan aidata seedetrakti liikuvust detomidiiniga ravitud hobustel, kuigi seda järeldust ei toeta kerakeste aeglasem eritumine vatinoksaani juuresolekul. Seetõttu on nende vastuoluliste tulemuste lahendamiseks vajalikud täiendavad uuringud. | est |
| dc.identifier.uri | http://hdl.handle.net/10492/9392 | |
| dc.publisher | Eesti Maaülikool | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | magistritööd | est |
| dc.subject | master thesis | eng |
| dc.subject | detomidine | eng |
| dc.subject | vatinoxan | eng |
| dc.subject | equine | eng |
| dc.subject | gastrointestinal effects | eng |
| dc.title | Effect of long detomidine constant rate infusion with and without vatinoxan on gastrointestinal motility in healthy horses | eng |
| dc.title.alternative | Pikkaajalise detomidiini püsiifusiooni mõju koos vatinoksaaniga ja ilma selleta tervete hobuste soolemotoorikale | est |
| dc.type | info:eu-repo/semantics/masterThesis | |
| rioxxterms.freetoread.startdate | 13.09.2024 |
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