Ülevaade koerte piimanäärme uudismoodustistest Eestis
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Kuupäev
2017
Kättesaadav alates
Autorid
Ajakirja pealkiri
Ajakirja ISSN
Köite pealkiri
Kirjastaja
Eesti Maaülikool
Abstrakt
Piimanäärme kasvajad on kõige sagedamini esinevad neoplaasiad emastel koertel, kellel
on munasarjad eemaldamata. Piimanäärme vähi tagajärjel sureb hinnanguliselt 20−55%
tabandunud koertest. Käesoleva retrospektiivse uurimustöö eesmärgiks on kirjeldada
piimanäärme uudismoodustiste esinemissagedust ja kliiniliselt tuvastatavaid riskifaktoreid
koertel Eestis. Viie aasta jooksul koguti 192 koeralt kokku 203 proovi, millele Eesti Maa-
ülikooli Veterinaarmeditsiini ja loomakasvatuse instituudi Veterinaaria alusteaduste ja
populatsioonimeditsiini osakonna patohistoloogia laboris diagnoos pandi. Töös kasutati
saadud andmete põhjal statistilise analüüsi teostamiseks programme MS Word 2013 ja R
3.2.3. Kõigist proovidest oli pahaloomulisi 65,5%. Healoomulised tuumorid olid statistiliselt
oluliselt väiksema diameetriga kui pahaloomulised (vastavalt 1,4 ja 3,4 cm),
p < 0,001. Diagnoosimise hetkel oli koerte keskmiseks vanuseks 9,0 aastat, kusjuures
vähiga koerad olid ülejäänutest vanemad (vastavalt 9,2 ja 8,5 aastat), p = 0,011. Uuringusse
kaasatud koertest avastati taksidel tugev eelsoodumus piimanäärme moodustiste
tekkimisele. Pahaloomulistest kasvajatest esines enim tubulaarset (20 juhtu), tubulopapillaarset
(20) ja kompaktset (15) kartsinoomi, healoomulistest kombineeritud adenoomi
(15) ja juhadesisest papillaarset (12) adenoomi ning segatüüpi kasvajat (11).
Mittekasvajalistest struktuuridest diagnoositi sagedasemalt piimajuhade ektaasiat (6) ja
epitelioosi (4). Üldjuhul olid töö tulemused kooskõlas kirjandusandmetega. Inimeste rinnavähk
sarnaneb mitmete tunnuste poolest koerte omale ja selle etioloogia ei ole veel
täielikult selge, mistõttu oleksid põhjendatud jätku-uuringud.
Mammary tumors represent the most frequently diagnosed neoplasms in intact female dogs. The reported mortality associated with canine mammary cancer ranges from 20% to 55%. The objective of this retrospective study was to describe the incidence and clinical risk factors of canine mammary tumors in Estonia. During a five-year period 203 samples were collected from 192 dogs and diagnosed at the Department of Basic Veterinary Sciences and Population Medicine, Institute of Veterinary Medicine and Animal Sciences of the Estonian University of Life Sciences. Statistical analysis was performed using MS Excel 2013 and R 3.2.3. The crude incidence of malignant neoplasms was 65.5%. Benign tumors were significantly smaller than malignant ones (1.4 versus 3.4 cm), p < 0.001. The median age of dogs at the time of diagnosis was 9.0 years, with dogs affected by cancer being on average older than the rest (9.2 versus 8.5 years), p = 0.011. A considerably high predisposition to neoplasms of the mammary gland was found in dachshunds. Tubular (20 cases), tubulopapillary (20) and solid (15) carcinoma were among the most frequently confirmed malignant neoplasms followed by benign complex adenomas (15), intraductal papillary adenomas (12) and mixed tumors (11). Duct ectasia (6) and epitheliosis (4) were the most commonly diagnosed nonneoplastic disorders. The results of this survey were generally in accordance with previously conducted studies. Future research is warranted as canine and human mammary tumors share many characteristics and the exact etiology remains unknown.
Mammary tumors represent the most frequently diagnosed neoplasms in intact female dogs. The reported mortality associated with canine mammary cancer ranges from 20% to 55%. The objective of this retrospective study was to describe the incidence and clinical risk factors of canine mammary tumors in Estonia. During a five-year period 203 samples were collected from 192 dogs and diagnosed at the Department of Basic Veterinary Sciences and Population Medicine, Institute of Veterinary Medicine and Animal Sciences of the Estonian University of Life Sciences. Statistical analysis was performed using MS Excel 2013 and R 3.2.3. The crude incidence of malignant neoplasms was 65.5%. Benign tumors were significantly smaller than malignant ones (1.4 versus 3.4 cm), p < 0.001. The median age of dogs at the time of diagnosis was 9.0 years, with dogs affected by cancer being on average older than the rest (9.2 versus 8.5 years), p = 0.011. A considerably high predisposition to neoplasms of the mammary gland was found in dachshunds. Tubular (20 cases), tubulopapillary (20) and solid (15) carcinoma were among the most frequently confirmed malignant neoplasms followed by benign complex adenomas (15), intraductal papillary adenomas (12) and mixed tumors (11). Duct ectasia (6) and epitheliosis (4) were the most commonly diagnosed nonneoplastic disorders. The results of this survey were generally in accordance with previously conducted studies. Future research is warranted as canine and human mammary tumors share many characteristics and the exact etiology remains unknown.
Kirjeldus
Loomaarstiõppe lõputöö
Veterinaarmeditsiini õppekaval
Märksõnad
magistritööd, vähid, hüperplaasia, düsplaasia, riskifaktorid, patohistoloogia