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Bacillus smithii TBMI12 as a potential probiotic feed additive

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Date
2014
Author
Suitso, Indrek
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Abstract
The purpose of the thesis was to investigate the potential of Bacillus smithii strain TBMI12 as a probiotic feed additive. For that safety, colonization, tolerance and challenge studies were performed with mice and pigs. Experiments showed that this strain is able to colonize gastrointestinal tract without harming the host or causing significant changes in the microbiota or disrupting the biodiversity of the gastrointestinal tract. Also colonization of the gastrointestinal tract with the Bacillus smithii TBMI12 endospores decreased the probability of Salmonella Enteritidis infection and decelerated the process of pathogenesis. Based on the results this strain has a potential to be probiotic feed additive.
 
Doktoritöö eesmärgiks oli hinnata sporogeense Bacillus smithii tüve TBMI sobivust probiootiliseks söödalisandiks. Selleks viidi läbi ohutus-, koloniseerimis-, tolerantsi- ja nakkuskatsed hiirte ning sigadega. Nende käigus selgus, et antud tüvi oli võimeline koloniseerima nende loomade soolestikku, kahjustamata sealjuures peremeeslooma või selle soolestiku normaalse mikrofloora tasakaalu ning bioloogilist mitmekesisust. Lisaks täheldati, et soolestiku eelnev koloniseerimine Bacillus smithii TBMI12 endospooridega vähendas Salmonella Entritidis’ega nakatumise tõenäosust ja aeglustas infektsiooni kulgu. Tulemuste põhjal saab eeldada, et antud tüvi võiks sobida probiootiliseks
 
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http://hdl.handle.net/10492/1898
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DSpace software copyright © 2002-2016  DuraSpace
All items in EMU digital archive DSpace are protected by original copyright, with all rights reserved, unless otherwise indicated.
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