Andmebaasi logo

2. Magistritööd

Selle kollektsiooni püsiv URIhttp://hdl.handle.net/10492/2498

Sirvi

Sirvi 2. Magistritööd Märksõna "adverse effects" järgi

Nüüd näidatakse 1 - 2 2
  • Pisipilt
    Kirje
    The most common tick repellents used by dog owners in Finland and their most frequently reported adverse effects
    (Eesti Maaülikool, 2022) Nummelin, Amanda; Tummeleht, Lea
    The need of use of tick repellent products in dogs is increasing in Finland. Ticks are active almost throughout the year, except for the cold winter months. Ticks act as vectors for many diseases like Lyme borreliosis and tick-born encephalitis. These diseases can be life threatening to humans as well as to the pet animals like dogs. Tick repellents and manually removing ticks are the only effective method for preventing these harmful diseases occurring. In Finland there is a great variety in tick repellent products. There are topical spot-on products, collars and systemically administered chewing tablets. These tick repellent products have been studied to be safe but as the need of use is increasing further studies are required. The study material was collected in the form of online questionnaire, in total 865 responses were received, number of answers varied between questions. Results indicated that majority of owners were using some type of repellent products, only 14.3 % (n =124) answered that they don’t use any repellent products. According to the responders the two most used repellent products in Finland were chewing tablet Bravecto and spot-on Bayvantic vet. Results showed that all used products can be considered relatively safe. 89.1 % (n = 647) of responders had not noted any dermatological signs, 95.5 % (n = 686) of responders had not noted any gastrointestinal signs, 95.6 % (n = 691) had not noted any neurological signs and 98.6 % (n = 707) had not noted any respiratory tract signs after using any type of tick repellent product. In this study population there were only single individual cases that had encountered some type of adverse effects.
  • Pisipilt
    Kirje
    Side effects of omeprazole in dogs – data analysis and case reports
    (Eesti Maaülikool, 2024) Heikkinen, Maisa Kirsikka; Rinkinen, Minna (advisor); Orro, Toomas (advisor)
    In the field of veterinary medicine, there's a prevalent tendency to excessively prescribe proton pump inhibitors (PPIs), often straying from established guidelines. Dogs experiencing vomiting, suspected gastritis, or as a preventive measure for various diseases frequently receive these medications, despite limited evidence supporting their efficacy. Two case reports serve as illustrations, detailing the nature and repercussions of adverse effects (AE) resulting from omeprazole. Furthermore, a concise analysis of data from the patient information system of a Finnish small animal clinic chain sheds light on commonly observed AE associated with omeprazole treatment. According to the analysis vomiting was the primary side effect noted with omeprazole administration. Additionally, other adverse reactions observed encompassed diarrhea, hyporexia or anorexia, lethargy, abdominal pain, restlessness, and increased defecation. Throughout the course of PPI therapy, the increased intragastric pH has the potential to induce hypergastrinemia, which in turn can lead to hyperplasia of enterochromaffin-like (ECL) cells and contribute to increased secretory capacity in parietal cells. Additionally, omeprazole may induce qualitative, quantitative, or both alterations in the small intestinal microbiota, promoting the colonization of nitrite-reducing bacteria in the stomach. This colonization is thought to escalate the production of potentially carcinogenic N-nitroso compounds. Upon discontinuation of omeprazole therapy, hypertrophic ECL cells can further stimulate gastric acid secretion, resulting in rebound acid hypersecretion (RAHS). This phenomenon may present with various acid-related symptoms such as heartburn, acid regurgitation, or dyspepsia, potentially prompting a reassessment of therapy. To mitigate the numerous potential AE associated with omeprazole, its use should consistently align with clear evidence supporting its specific indication. This approach is essential to prevent unnecessary administration of the medication and the potential harm it may cause to animals. Additionally, clinicians should recognize potential AE associated with administering omeprazole to dogs, enabling them to modify therapy as necessary.