Andmebaasi logo

2. Magistritööd

Selle kollektsiooni püsiv URIhttp://hdl.handle.net/10492/2498

Sirvi

Sirvi 2. Magistritööd Märksõna "acute phase response" järgi

Nüüd näidatakse 1 - 1 1
  • Pisipilt
    Kirje
    Associations of acute phase proteins with bovine respiratory disease in calves
    (Eesti Maaülikool, 2024) Askola, Johanna; Orro, Toomas (advisor)
    Bovine respiratory disease (BRD) is a global problem with long-lasting morbidity and increased mortality. It causes economic losses and compromises animal welfare throughout production chain. Clinical and subclinical BRD complicates growth and fertility, lowers productivity and overall quality of animals. BRD weakens immunity making bovine susceptible to infections. BRD is difficult to prevent, treat and diagnose as it is a combination of multiple challenges such as poor calf management and high pathogen load at farm. In BRD pathogens and tissue trauma provoke local cells to produce proinflammatory cytokines that promote systemic inflammatory response called acute phase response (APR) to stimulate hepatic production of acute phase proteins (APPs) such as fibrinogen (Fb), haptoglobin (Hp) and serum amyloid A (SAA). Fb, Hp and SAA concentrations increase in inflammatory and infectious conditions making them promising biomarkers to use in detection of calves with clinical or subclinical BRD. 150 calves aged 2-86 days, from 15 Estonian dairy farms were selected for the study concerning possible associations of Fb, Hp and SAA concentrations in calves with respiratory symptoms. APPs were used as markers for APR. Blood samples were collected from ten calves on each farm, five calves suspected to have APR (APR+) and five calves non-suspected to have APR (APR-). APP concentrations were examined, and multivariable linear mixed-effects regression models were used to analyse the associations. Increased Fb concentrations were associated with rectal temperature >39.5°C, increased respiratory rate >50 breaths/min and coughing. Increased Hp concentrations were in calves with rectal temperature of 39°C and above. Increased SAA concentrations were associated with rectal temperature >39.5°C and respiratory rate of 40-50 breaths/min. Thus, clinical respiratory symptoms promoted APR. Together with clinical examination of calves APPs could be used to detect calves with underlying APR and identify those in need of medical treatment.