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VLI lõputööd

Selle valdkonna püsiv URIhttp://hdl.handle.net/10492/2470

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Sirvi VLI lõputööd Märksõna "ainuraksed" järgi

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  • Pisipilt
    Kirje
    Impact of Gastrointestinal Protozoan Infections on the Acute Phase Response in Neonatal Ruminants
    (Eesti Maaülikool, 2019) Niine, Tarmo; Orro, Toomas (advisor); Lassen, Brian (advisor); Lepenies, Bernd (opponent)
    After birth, neonatal ruminants go through crucial and sensitive period of rapid development and growth. During this period, they may interact with variety of microorganisms found in the surrounding environment. It would be beneficial for both the farmer and the veterinarian to have general biomarkers, useful in managing of this adaptation process. Such a tool could help in improving the prediction of the animals’ performance in the herd. The interactions between the ruminant and infectious agents can damage tissues in the host and trigger the innate immune response starting with the acute phase response (APR). This process can lead to an increase or decrease of specific acute phase proteins (APPs) in the blood serum. Fluctuations in concentrations of APPs may serve as proxies for assessing the inflammatory processes during the adaptation period of newborn animal. Particularly when the animal is transitioning from a low microbe environment in the uterus to the high microbe environment of the extrauterine life. In addition, there is growing evidence, that strong APR in the first weeks of life could influence the success as a production animal, such as the growth rate. The studies presented in the dissertation were longitudinal studies and each study focused on different ruminant species: reindeer calves, dairy calves and lambs. In each study, the focus was on the neonatal period (first three weeks of age), during which blood and faecal samples were collected and the growth rate was measured. In the study of lambs, a significant association with APPs was found at second week of life and the growth rate. Similar result was seen dairy calves that had an APR during the neonatal period, which had a negative association with the growth rate in older age. Additionally, Cryptosporidium infections was associated as a positive effect with APR in dairy calves. In reindeer calves, the APR was had a positive association with Giardia infections. In conclusion, current results offers promise of developing more precise indicators for measuring the outcome of the adaptation process of the immune system during the neonatal period.