Sirvi Autor "Granholm, Heidi Enneli" järgi

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Effects of cobalt nanoparticles on Microsporum canis in vitro
(Eesti Maaülikool, 2022) Granholm, Heidi Enneli; Praakle, Kristi (juhendaja); Rauwel, Erwan (juhendaja)
Dematophytosis is a common infectious skin disease caused by various fungi of the Microsporum, Trichophyton and Epidermophyton species. Microsporum canis (M. canis) is causing dermatophytosis in small animals, and it is a zoonotic disease. Treatment of dermatophytosis ensures milder clinical signs and faster recovery. Cobalt nanoparticles (Co NPs) are currently being researched in order to find therapeutic uses, such as anti-cancer, anti-microbial and anti-fungal properties. The aim of this thesis was to study the antifungal effect of cobalt nanoparticles on the growth of M. canis. Our study was a laboratory study carrying out experiments in vitro. Mixtures of different concentrations of Co NPs with Aloe vera gel and Phosphate Buffered Saline solution were created to test the antifungal properties against dermatophyte M. canis. The results showed that where Co NPs were used, there was no growth of M. canis. The Co NPs are exhibiting an antifungal effect and more research should be done investigating further and on the toxicity. Co NPs could possibly be considered a future treatment of dermatophytosis caused by M. canis.